Jeffrey T. Henderson, Nadine A. Seniuk, andJohn C. Roder
Samuel Lunenfeld Research Institute, Mount SinaiHospital,
Program and Development and Fetal Health, 600University Ave., Toronto, Ontario M5G-1X5
Mouse Genome, 91(3), pp. 561-563,1993
Abstract
Ciliary neurotrophic factor (CNTF)is a 23 kDa cytoplasmic protein which is produced in astrocytes in the central nervous system and myelinating Schwann cells in the peripheral nervous system. This factor has been shown to promote the survival of sensory, sympathetic, parasympathetic and motor neurons in vitro. In vivo, CNTF has been shown to prevent programmed motor neuron death; as well as the axotomy-induced death of motor neurons in the facial nucleus and cholinergic neurons in the medial septum. In order to more precisely map Cntf withrespect to other neurological loci, we have analyzed a series of C57Bl/6Jx DBA/2J (BXD) recombinant inbred strains, by restriction fragment length polymorphism (RFLP). The strain distribution pattern (SDP) for Cntf demonstrates tight linkage to Osbp on murine chromosome 19.
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