PHM142 - Metabolic Biochemistry and Immunology


Overview:

This course examines the biochemistry and regulation of human metabolic pathways, together with the clinical implications of derangement of these systems. The mechanism of relevant drug action, as well as the underlying cellular anatomy of affected organs/systems is also stressed. This course also provides students with an introduction to principles of immunology and the regulatory mechanisms utilized by drugs which alter immune response.

The weekly lecture period totals three hours including student presentation. Students whom wish to sign up for presentations (groups of 4 or less) may do so at the location indicated (see presentations). Additional information available under the "Student presentations" link. Lecture notes are available under the "course lecture" link in one of two e-formats. Exam questions are drawn from lecture material, course handouts and class discussions.

Texts recommended (but not required) for the course include:
"Textbook of Biochemistry with Clinical Correlations" 7th ed. (Devlin),
"Biochemistry" 6th ed. 7th ed. (Berg, Tymoczko and Stryer),
"Lippincott's Illustrated Reviews, Immunology" 2nd ed. (Doan, Melvold, Viselli, Waltenbaugh),
"Janeway's Immunobiology" 8th ed. (Murphy).



Course Information:

Class term: September 5th - November 29th
Tuesday 10 - 11am (With the exception of QUIZ dates, Tuesdays are VIRTUAL Presentations days).
Thursday 10 - 12pm (Currently: IN PERSON - PB150)



Announcements:

Note concerning institutional copyright procedures:
Instructors present materials for which they have obtained legal copyright permission for sole use in this course. Posting of such materials to third party sites constitutes a violation of the right to use conditions for such materials. Such reproduction is an infringement of copyright and is strictly prohibited. If a student wishes to indpendently record, photograph or otherwise reproduce components of the lecture presentations, course notes or other materials provided by instructors, they must obtain the instructor's prior written consent.

Notice concerning use of artificial intelligence (AI):
Unless otherwise noted by the instructors, use of AI tools such as ChatGPT and equivalent for PHM142 projects is prohibited.

Official Notice from University:
Accessibility Services is seeking volunteer note takers for students in this class who are registered in Accessibility Services. By volunteering to take notes for students with disabilities, you are making a positive contribution to their academic success. By volunteering as a note-taker, you will benefit as well - It is an excellent way to improve your own note-taking skills and to maintain consistent class attendance. At the end of term, we would be happy to provide a Certificate of Appreciation for your hard work - please contact our office at as.notetaking@utoronto.ca. You may also qualify for a Co-Curricular Record by registering your volunteer work on CLNX before the end of June. We also have a draw for qualifying volunteers throughout the academic year.
Steps to Register as a Volunteer:
1. Register Online as a Volunteer Note-Taker at: https://clockwork.studentlife.utoronto.ca/custom/misc/home.aspx
2. For a step-to-step guide please follow this link to the Volunteer Notetaking Portal Guide
3. Click on Volunteer Notetakers, and sign in using your UTORid
4. Select the course(s) you wish to take notes for. Please note: you do NOT need to upload sample notes or be selected as a volunteer to begin uploading.
5. Start uploading notes.
Interested parties can email: as.notetaking@utoronto.ca if you have questions or require any assistance with uploading notes. If you are no longer able to upload notes for a course, please also let us know immediately . For more information about the Accessibility Services Peer Notetaking program, please visit Student Life Volunteer Note Taking . Thank you for your support and for making notes more accessible for our students. AS Note-taking Team.

OTHER OFFICAL FACULTY OF PHARMACY POLICY STATEMENTS: 2024 Pharmacy Statements here


Posted August 7th, 2024:
As per fair use agreements, TUESDAY at 10 am will be the time at which course lectures for the current week will become active.
Student Presentation are required to be submitted by Tuesday at 10 AM OTHER THAN WEEK 2 (which is Thursday at 10 am). Questions / office hours are held 11 - 12pm Tuesday and 12-1pm Thursday.

Posted August 20th, 2024:
PHM142 Sign-up Sheet will be active as of Sept. 5th (sign-ups prior to this date will be removed). Student presentations are distributed on a first come first serve basis. See student presentations for further details. Student Presentations: Note that with respect to SUMMARY sheets, these can be placed WITHIN the presentation - no need for submission of a separate sheet. Note also that there is no need to submit a SEPARATE set of PowerPoint slides with your submission. For submissions, the most straightforward format to submit your group presentation as an .MP4 format file. Only ONE copy of your presentation needs to be submitted per group.

Posted August 7th, 2024:
First day of class is THURSDAY, September 5th, 10-12pm in room PB150.

Posted Sept 12th, 2024:
For STUDENT PRESENTATIONS: Current group member lists now posted on presentation page. For student signing up on Sept. 12th, Dr. Bowen's TAs will assign topics with DUE DATE will be posted when available.

Posted Sept 19th, 2024:
Revised Unit 3 Lecture slides now posted.

Posted Sept 24th, 2024:
Ancillary presentation list now posted.

Posted Oct. 10th, 2024:
NOTE: Bowen Li Lecture 6 now posted.

Posted Oct. 10th, 2024:
NOTE: For coming MIDTERM EXAM - NO STUDENT PRESENTATIONS WILL BE USED FOR TEST.

Posted Nov. 18, 2024:
NOTE: QUIZ #2 WILL COVER MATERIALS FROM LECTURES 7, 8, 9 AND 10 ONLY. No student presentations will be utilized for this exam.




Navigating the course Website:

For a copy of the course outline, or to download course lectures, click on the "COURSE OUTLINE" or "COURSE LECTURE" links below in the the "COURSE SECTIONS" segment below. For a breakdown of exam and assignment weighting and our examination and missed exam policy, click on the "GRADING AND POLICIES" link below.

In the event of additions, clarification, or modification to class materials following their presentation, this information will be appended to the appropriate "COURSE LECTURE" or "STUDENT PRESENTATION" PDF within 24 hours of its presentation. Assignment due dates, and the time and location of scheduled exams can be found by clicking the "EXAMS / ASSIGNMENTS / DATES" link below. General class NOTICES will also be provided on this page under "Announcements".



Biochemical Definitions:

For explanations and definitions of biochemical terms used in class, please refer to "The Oxford Dictionary of Biochemistry and Molecular Biology" (QD415A25094, 2000) in the science library. Be sure to refresh or reload your browser window to view updated material.



Instructor Contact Information:

Dr. Jeffrey Henderson
Pharmacy building, Rm 903
Phone: 416-946-3090
Office hours: Tuesday 11-12 pm, Thursday 12-1 pm
Email: jeff.henderson@utoronto.ca


Dr. Bowen Li
Pharmacy building, Rm 901
Phone: 416-946-5571
Office hours: Tuesday 11-12 pm, Thursday 12-1 pm
Email: bw.li@utoronto.ca


Course TA's:

Shudi Huang                   shudi.huang@mail.utoronto.ca          (962 - Henderson)

Sako Mirzaie                    s.mirzaie@utoronto.ca                      (1162 - Henderson)

Jingan (Charles) Chen   charless.chen@mail.utoronto.ca        (952 - Bowen Li)

Alaa Selim                       alaa.selim@utoronto.ca                    (952 - Bowen Li)

*TA office hours are: Thursday 12-1 pm



Course Sections: (double click)

Course Outline | Course Lectures | Grading and Policies | Exams / Assignments / Dates

Student Presentations | Example Presentations | Student Grades: see Quercus

3D Molecular Viewer: Oxy-Hb | 3D Molecular Viewer: Deoxy-Hb | Protein Database


Download Acrobat Reader if needed.




Useful biochemical Links:

     Protein Data Bank (PDB) master index 

     Molecules in Motion (Hemoglobin) 

     Hemoglobin Biochemistry 

     Biochemical Pathways 

     Interactive Biochemistry 



Course Break:
How do mice handle their biochemistry assignments ?                             But that's only because they are on  DRUGS !


Metabolism . . . the rock and roll version      HERE.






 Site Navigation:


     Faculty of Pharmacy Homepage 

     University of Toronto Homepage 

     Henderson Laboratory Homepage

      Site administrator: Dr. Henderson: jeff.henderson@utoronto.ca